Toshiro Okazaki Selected Research

Sphingomyelins

9/2022	Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells.
11/2021	Role of ceramide/sphingomyelin (SM) balance regulated through "SM cycle" in cancer.
9/2020	Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models.
11/2016	Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus.
1/2016	Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow.
6/2015	Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies.
5/2014	The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration-from cell and animal models to human disorders.
10/2012	A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate.
9/2011	Regulation of death and growth signals at the plasma membrane by sphingomyelin synthesis: implications for hematological malignancies.
8/2011	Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes.

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Toshiro Okazaki Research Topics

Disease

16	Neoplasms (Cancer) 09/2022 - 01/2002
10	Leukemia 09/2022 - 07/2002
5	Lymphoma (Lymphomas) 01/2020 - 01/2010
4	Inflammation (Inflammations) 11/2021 - 04/2011
3	Hematologic Neoplasms (Hematological Malignancy) 06/2015 - 05/2005
3	Multiple Myeloma 06/2015 - 07/2005
2	Neoplasm Metastasis (Metastasis) 09/2022 - 01/2020
2	Thrombocytopenia (Thrombopenia) 10/2021 - 01/2013
2	Splenomegaly 10/2021 - 02/2014
2	Immunoglobulin G4-Related Disease 05/2020 - 01/2015
2	Diabetes Mellitus 01/2020 - 01/2005
2	Obesity 01/2020 - 08/2011
2	Squamous Cell Carcinoma of Head and Neck 06/2015 - 04/2011
2	T-Cell Leukemia (Leukemia, T Cell) 04/2012 - 03/2006
2	Hodgkin Disease (Hodgkin's Disease) 05/2009 - 03/2007
2	Atherosclerosis 01/2005 - 01/2004
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Chronic Disease (Chronic Diseases) 09/2020
1	Necrosis 09/2020
1	Polyps 01/2018
1	Carcinoma (Carcinomatosis) 01/2018
1	Colitis-Associated Neoplasms 01/2017
1	Depressive Disorder (Melancholia) 01/2017
1	Colitis 01/2017
1	Infections 11/2016
1	Meningitis 11/2016
1	Cysts 06/2016
1	Polyploidy 01/2016
1	Vasculitis (Vasculitides) 01/2016
1	B-Cell Lymphoma (Lymphoma, B Cell) 09/2015
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 09/2015
1	Head and Neck Neoplasms (Head and Neck Cancer) 06/2015
1	Hypoxia (Hypoxemia) 09/2014
1	Stroke (Strokes) 08/2014
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2014
1	Autoimmune Diseases (Autoimmune Disease) 02/2014
1	Avitaminosis (Vitamin Deficiency) 02/2013
1	Virus Diseases (Viral Diseases) 02/2013
1	Fever (Fevers) 01/2013
1	Edema (Dropsy) 01/2013
1	Pleural Effusion (Pleural Effusions) 01/2013
1	Septic Shock (Toxic Shock Syndrome) 01/2013
1	Fibrosis (Cirrhosis) 01/2013
1	Multi-centric Castleman's Disease 01/2013

Drug/Important Bio-Agent (IBA)

18	CeramidesIBA 09/2022 - 01/2003
11	phosphatidylcholine-ceramide phosphocholine transferaseIBA 09/2022 - 01/2003
10	SphingomyelinsIBA 09/2022 - 08/2011
8	LipidsIBA 09/2020 - 01/2003
7	SphingolipidsIBA 01/2021 - 05/2005
6	CytokinesIBA 01/2017 - 01/2002
4	SteroidsIBA 05/2020 - 01/2010
4	EnzymesIBA 06/2016 - 01/2005
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2015
3	Immunoglobulin G (IgG)IBA 05/2020 - 03/2007
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 03/2007
3	Interleukin-6 (Interleukin 6)IBA 11/2016 - 05/2012
3	ceramide glucosyltransferaseIBA 01/2016 - 01/2003
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2022 - 01/2013
2	RNA (Ribonucleic Acid)IBA 05/2020 - 01/2015
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2016 - 01/2005
2	AntigensIBA 01/2016 - 03/2007
2	Glucosylceramides (Glucocerebrosides)IBA 06/2015 - 04/2011
2	LeptinIBA 02/2014 - 01/2012
1	ZinostatinIBA 01/2022
1	Inosine Triphosphate (ITP)IBA 10/2021
1	dihydroceramide desaturaseIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	bactericidal permeability increasing proteinIBA 05/2020
1	Transcobalamins (Transcobalamin II)IBA 05/2020
1	Secretory Leukocyte Peptidase InhibitorIBA 05/2020
1	LactoferrinIBA 05/2020
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2020
1	Cell Adhesion MoleculesIBA 01/2020
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2017
1	AzoxymethaneIBA 01/2017
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2017
1	ChemokinesIBA 01/2017
1	Dextrans (Dextran)FDA Link 01/2017
1	Messenger RNA (mRNA)IBA 06/2016
1	Psychosine (Galactosylsphingosine)IBA 01/2016
1	Cladribine FDA LinkGeneric 09/2015
1	Rituximab (Mabthera)FDA Link 09/2015
1	Mitoxantrone (Novantrone)FDA LinkGeneric 09/2015
1	Dexamethasone (Maxidex)FDA LinkGeneric 09/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2015
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 06/2015
1	Eosine Yellowish-(YS) (Eosin)IBA 06/2015
1	Hematoxylin (Haematoxylon)IBA 06/2015
1	SphingosineIBA 06/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2014
1	Etoposide (VP 16)FDA LinkGeneric 01/2013
1	Vincristine (Oncovin)FDA LinkGeneric 01/2013
1	C-Reactive ProteinIBA 01/2013
1	Prednisolone (Predate)FDA LinkGeneric 01/2013

Therapy/Procedure

10	Therapeutics 01/2021 - 05/2005
1	Transplantation 01/2017
1	Intraperitoneal Injections 11/2016
1	Aftercare (After-Treatment) 06/2015
1	Radiotherapy 08/2014